Table 1.
Imaging modalities and acquired parameters.
| Sequence | Measures | Parameters: Siemens Skyra sequences |
|---|---|---|
| 3D T1-weighted MEMPRAGE (Multi-Echo Magnetization Prepared Rapid Acquisition Gradient Echo) |
Subcortical and cortical tissue volumes; Surface-wise measures including cortical thickness, surface area and gyrification. |
Sagittal orientation; Repetition time (TR) = 2530 ms; echo time (TE) = 1.69, 3.54, 5.39, 7.24 ms; flip angle = 7.0°; voxel size 1.0 × 1.0 × 1.0 mm3; inversion time (TI) = 1100 ms; field of view (FOV) = 224 × 224 × 176 mm; 176 slices, 1.0 mm thick. Scan time: 5min21s. |
| Resting state blood-oxygen-level dependent (BOLD) echo planar imaging (EPI) | Resting brain networks. | TR 2000 ms; TE 30 ms; flip angle = 77°, 33 slices, slice thickness 4 mm; slice gap 1 mm, voxel size 3.4 × 3.4 × 4.0 mm. FOV = 220 × 220mm, Scan time 8min04s. |
| Single voxel PRESS (Point RESolved Spectroscopy) magnetic resonance spectroscopy (MRS) |
Relative metabolite concentrations of phosphocreatine (Cr + PCr), glutamate with glutamine (Glx), glutamate (Glu), n-acetyl-aspartate with n-acetyl-aspartyl-glutamate (NAA + NAAG), n-acetyl-aspartate (NAA), choline containing metabolites (glycerophosphocholine + phosphocholine [GPc + PCh]), and myo-inositol (mI). |
Voxel 1: Midline parietal grey matter. Voxels 2 and 3: Left and right parietal white matter. TR = 2000 ms, TE = 30 ms (128 averages) with water references (TE = 30, 75, 100, 144, 500, 1000 ms); Voxel size 25 × 25 × 25 mm3. Scan time: ~6 min total per voxel with water references. |
| Diffusion Tensor Imaging (DTI) | Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). | A pair of diffusion-weight datasets with opposite phase encoding (anterior-posterior and posterior-anterior) were acquired using 30 noncollinear gradient directions with DWfactor b = 1000 s/mm2, and one non-DW b = 0s mm2 (b0) acquisition); TR = 7800 ms; TE = 92 ms; voxel size = 1.8 × 1.8 × 2.0 mm3, FOV = 230 x 230 x 121 mm, slice thickness 2.0 mm, Scan time: 2 × 8min36s. |
| 3D Sagittal T2-weighted structural imaging | Subcortical and cortical tissue volumes. | TR = 3200 ms; TE = 409 ms; FOV = 230 × 230 mm; voxel size = 0.9 × 0.9 × 1.0 mm3; 160 slices, 1.0 mm thick. Scan time: 3min7s |