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Vaccines against Ebola Virus
| Vaccine | rAd5/ChAd3 | rVSV/ΔG/GP EBOV |
|---|---|---|
| Replication potential | Replication deficient | Replication competent |
| Mechanism of protection | CD8+ T cell mediated | Antibody mediated |
| Booster requirement | Modified vaccinia Ankara | |
| Durability | 10 months with booster vaccination in nonhuman primates | 12-18 months in rodents 14 months in nonhuman primates (MARV) |
| Clinical trial | Phase II/III | Phase II/III |
