TABLE 1.
Fractional transfer coefficients for the 6-compartment models of vitamin A metabolism in CN, ID–, and ID+ rats1
| Value (FSD)3 | |||
|---|---|---|---|
| L(I,J)2 | CN (day−1) | ID– (day−1) | ID+ (day−1) |
| L(1,2) | 9.69 (0.09) | 23.19 (0.06) | 23.19 |
| L(1,3) | 0.091 (0.05) | 0.249 (0.03) | 0.2489 |
| L(1,4), before day 21 | 0.200 (0.01) | 0.013 (0.02) | 0.013 |
| L(1,4), after day 21 | 0.200 (0.01) | 0.013 (0.02) | L(1,4) = -P(1)*T*T + P(2)*T + P(3)5 |
| L(30,4), before day 21 | 11.13/F244 | 0.006 (0.04) | 0.006 |
| L(30,4), after day 21 | 11.13/F244 | 0.006 (0.04) | L (30,4) = -P(5)*T*T + P(6)*T + P(7)5 |
1
CN, control group; ID–, iron-deficient group; ID+, iron-repletion group.
2
L(I, J)s represent the fraction of vitamin A in compartment J that is transferred to compartment I each day, data shown here are model-predicted values of each parameters with model-estimated FSDs in parentheses.
3
FSD, fractional SD.
4
F24 is the model-predicted compartment mass for compartment 24.
5
Two quadratic equations define L(1,4) and L (30, 4) as time-dependent variables, where P(1), P(2), P(3), P(5), P(6), and P(7) are 2.23 × 10−6, 5.42 × 10−4, 8.99 × 10−3, 1.72 × 10−7, 1.57244 × 10−4, and 1.03 × 10−2, respectively. T, time (d) after dosing.