Table 1.
FIC and BI analysis of 30 azole-susceptible or -resistant A. fumigatus isolates
| No. of isolates | Resistance genotype | ISA MIC (mg/L)a | FIC1 |
FIC2 |
BI, sum ΔE, mean (range) | ||||
|---|---|---|---|---|---|---|---|---|---|
| synergism (≤0.5) | indifference (0.5–4) | antagonism (>4) | synergism (≤0.5) | indifference (0.5–4) | antagonism (>4) | ||||
| 6 | TR34/L98H | 7.12 (4–>8) | 6 | 6 | 89.33 (−24 to 408) | ||||
| 2 | TR46/Y121F/T289A | >8 (>8) | OOR | OOR | −9.5 (−19 to 0) | ||||
| 10 | cyp51A point mutations | 0.63 (0.25–8) | 2 | 8 | 7 | 3 | 89 (−109 to 362) | ||
| 12 | WT isolates | 0.59 (0.25–4) | 12 | 7 | 5 | 201.83 (−112 to 522) | |||
ISA, isavuconazole; OOR, out of range.
a
Values shown are GM (range).