Figure 4.

Illustration of the effect of the covariates eGFR (mL/min) and serum albumin concentration (g/L) on the concentration–time curve of flucloxacillin as assessed by Monte Carlo simulations of the first 24 h of treatment of a virtual critically ill patient, with all median characteristics of the population, but with two different eGFR values and two different serum albumin concentrations. Both total and unbound flucloxacillin concentrations were simulated for two different IV dosing regimens: (a) total flucloxacillin concentrations after 1 g q6h; (b) unbound flucloxacillin concentrations after 1 g q6h; (c) total flucloxacillin concentrations after 2 g q4h; and (d) unbound flucloxacillin concentrations after 2 g q4h. Alb, serum albumin concentration.