Table 3.
Predictive performance of the structural and final model in two external datasets
| Brisbane external dataset (n = 20) |
Nijmegen external dataset (n = 14) |
|||||
|---|---|---|---|---|---|---|
| Characteristics | structural model | final model | P | structural model | final model | P |
| Total flucloxacillin | ||||||
| error (%) | NA | NA | 18.1 (−54.8 to 66.4) | −11.0 (−57.1 to 28.3) | 0.0005 | |
| absolute error (%) | NA | NA | 55.3 (28.5–77.6) | 39.6 (19.2–59.6) | 0.004 | |
| Unbound flucloxacillin | ||||||
| error (%) | −59.4 (−83.4 to 14.3) | −5.80 (−36.9 to 29.7) | 0.01 | −49.1 (−86.1 to 9.80) | −27.8 (−64.5 to 21.2) | 0.04 |
| absolute error (%) | 70.3 (40.4–92.0) | 33.4 (10.9–58.4) | 0.0005 | 59.2 (32.3–88.9) | 51.7 (25.2–74.9) | 0.01 |
Values are expressed as median (IQR). A one-sided Wilcoxon matched-pairs test was used to test differences between the performance of the structural model and the final model. NA, not available.