Table 2.
Comparison of psychopharmacological treatment between the 6 months preceding and the 6 months following clozapine and paliperidone palmitate combination.
| 6 months before | 6 months after combination treatment | Statistic | p value | |
|---|---|---|---|---|
| Subjects taking clozapine | 32/50 (64%) | 50/50 (100%) | ||
| Mean daily dose—mg/day (SD) | 330.47 (189.52) | 265.50 (164.82) | Z = −1.86 | p = 0.062 |
| Subjects taking paliperidone palmitate | 13/50 (24%) | 50/50 (100%) | ||
| Mean monthly dose—mg/month (SD) | 134.38 (34) | 123 (33.82) | Z = −0.68 | p = 0.49 |
| Subjects with other psychopharmacological treatments | ||||
| Antipsychotics | 40/50 (80%) | 9/50 (18%) | – | p < 0.001* |
| Anticholinergics | 10/50 (20%) | 6/50 (12%) | – | 0.22 |
| Antidepressants | 10/50 (20%) | 13/50 (26%) | – | 0.55 |
| Mood stabilizers | 14/50 (28%) | 11/50 (22%) | – | 0.25 |
| Benzodiazepines | 26/50 (52%) | 9/50 (18%) | – | p < 0.001* |
*
Significant value p < 0.05