Table 3.
Comparison of clinical results between the 6 months preceding and the 6 months following clozapine and paliperidone palmitate combination.
| 6 months before combination treatment | 6 months after combination treatment | Statistic | p value | |
|---|---|---|---|---|
| Mean number of hospitalizations (SD) | 0.86 (0.7) | 0.36 (0.63) | Z = -4.11 | p < 0.001* |
| Mean total duration of hospitalizations (days; SD) | 39.08 (53.61) | 18.26 (41.23) | Z = −3.02 | p = 0.002* |
| Mean number of visits to emergency services (SD) | 1.26 (1.7) | 0.46 (0.97) | Z = −3.57 | p < 0.001* |
| BPRS total score (mean; SD) | 18.32 (7.71) | 7.84 (5.16) | Z = -5.99 | p < 0.001* |
| Participants changes in BPRS total score | ||||
| Increase—n (%) | – | 2 (4) | – | – |
| <25% reduction n (%) | – | 4 (8) | – | – |
| 25–-49% reduction n (%) | – | 7 (14) | – | – |
| 50–-74% reduction n (%) | – | 28 (46) | – | – |
| >75% reduction n (%) | – | 9 (18) | – | – |
| PSP total score (mean; SD) | 46.06 (18.7) | 60.86 (18.68) | Z = −5.34 | p < 0.001* |
| Self-care | 1.54 (1.2) | 0.9 (0.95) | Z = −4.32 | p < 0.001* |
| Personal and social relationships | 2.68 (0.91) | 1.88 (1.02) | Z = −4.72 | p < 0.001* |
| Socially useful activities | 3.06 (1.15) | 2.08 (1.27) | Z = −5.07 | p < 0.001* |
| Disturbing and aggressive behavior | 1.14 (1.37) | 0.28 (0.67) | Z = −4.27 | p < 0.001* |
Abbreviations: BPRS: Brief Psychiatric Rating Scale; PSP: Personal and Social Performance scale; SD, standard deviation.
*
Significant value p < 0.05.