Table 4.
Comparison of tolerability results between the 6 months preceding and the 6 months following clozapine and paliperidone palmitate combination.
| 6 months before combination treatment | 6 months after combination treatment | Statistic | p value | |
|---|---|---|---|---|
| UKU total score (n = 50) | 10.76 (8.04) | 8.82 (6.63) | Z = −2.88 | p = 0.004* |
| UKU psychic side effects | 5.48 (4.13) | 3.92 (3.17) | Z = −2.84 | p = 0.004* |
| UKU neurologic side effects | 1.18 (1.67) | 0.74 (1.08) | Z = −2.12 | p = 0.034* |
| UKU autonomic side effects | 1.64 (2.16) | 1.7 (2.02) | Z = −0.56 | p = 0.96 |
| UKU other side effects | 2.46 (2.72) | 2.46 (2.72) | Z = 0 | p = 1 |
| Prolactin plasma levels (ng/ml; n = 8) | 41.46 (36.21) | 44.24 (42.79) | Z = −0.7 | p = 0.48 |
Abbreviations: UKU: Udvalg for Kliniske Undersogelser side effects scale.
*
Significant value p < 0.05.