Table 3.
Primary and secondary outcomes
| Outcome | TPE (n = 40) | Standard care (n = 40) | p |
|---|---|---|---|
| 28-day mortality | |||
| Total study population | 16 (40%) | 26 (65%) | 0.043 |
| Pneumonia group | 11/23 (47.8%) | 15/17 (88%) | 0.017 |
| Other groups | 5/17 (29.4%) | 11/23 (48%) | 0.332 |
| Hospital mortality | 17 (42.5%) | 26 (65%) | 0.072 |
| Baseline SOFA in 48 h survivorsa | 15.7 ± 3.0 | 13.2 ± 2.2 | < 0.001 |
| SOFA at 48 ha | 12.6 ± 4.5 | 12.9 ± 3.7 | 0.782 |
| Change in SOFAa | 3.1 ± 2.6 | 0.32 ± 3.5 | < 0.001 |
| Baseline Cardiac SOFA in 48 h survivorsa | 4.0 ± 0.17 | 3.8 ± 0.73 | 0.336 |
| Cardiac SOFA at 48 ha | 1.5 ± 1.54 | 2.8 ± 1.6 | 0.001 |
| Change in cards SOFAa | 2.47 ± 1.52 | 1.03 ± 1.52 | < 0.001 |
| New need for RRT during admissionb | 25 (67.6%) | 19 (51.4%) | 0.236 |
| Mortality associated with new RRT | 12 (48%) | 15 (79%) | 0.06 |
| New need for RRT at d/c in survivors | 4 (30.8%) | 1 (25%) | 1 |
| Net daily fluid balance preceding 24 h | 4304 ± 2900 | 5269 ± 3629 | 0.244 |
| Net daily fluid balance after 48 h | − 78 ± 1837 | 1466 ± 2675 | 0.01 |
| Change in fluid balance | − 4382 ± 2958 | − 3803 ± 4431 | 0.542 |
| ICU LOSc | 16.6 ± 15.8 | 8.0 ± 7.4 | 0.003 |
| Hospital LOSc | 24.6 ± 22.4 | 13.0 ± 13.2 | 0.006 |
aFor patients who survived at least 48 h (n = 34 for the TPE arm and n = 31 for the standard arm)
bThree ESRD in each group
cNote that the standard care arm experienced more 28-day mortality