Table 5.
Effect of TPE on objective measures of organ dysfunction compared to controls
| Measure | TPE (n = 40) | Standard care (n = 40) | p |
|---|---|---|---|
| Cards SOFA at time zeroa | 4.0 ± 0.16 | 3.9 ± 0.65 | 0.348 |
| Cards SOFA at 48 h | 1.5 ± 1.54 | 2.8 ± 1.6 | 0.001 |
| Lactate at time zeroa | 8.1 ± 6.6 | 6.6 ± 4.7 | 0.219 |
| Lactate at 24 h | 4.8 ± 5.9 (n = 29) | 6.9 ± 5.5 (n = 35) | 0.145 |
| Platelet count at time zeroa | 102.6 ± 68.5 | 172.8 ± 72.7 (n = 37) | < 0.001 |
| Platelet nadir | 49.7 ± 36.6 | 73.7 ± 41.9 | 0.008 |
| P/F ratio at time zeroa | 176.3 ± 139.2 (n = 38) | 161.8 ± 113.3 (n = 33) | 0.631 |
| P/F ratio at 48 h | 217 ± 100 (n = 29) | 223.6 ± 144.3 (n = 30) | 0.838 |
| Extubations | 3 | 1 | |
| New intubations | 0 (1 placed on ECMO) | 5 | |
| Deaths prior to 48 h | 6 | 9 | 0.568 |
aTPE “time zero” is the time of the first TPE; standard care “time zero” is the hour of the first recorded vital signs in ICU
Lactic acid measured mmol/L; platelet count measured × 1000/μL