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. 2020 Aug 24;8:144. doi: 10.1186/s40478-020-01020-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — RNAseq shows differences in CNS-immune cell activation between CBE-treated and SVNI-infected mice. a Table summarizing the number of differentially expressed genes from RNAseq analysis of the brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. The numbers indicate the numbers of genes that were twofold of control, p < 0.05. n = 3 for each group. b Heat maps of RNAseq data comparing differentially expressed genes in brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. A horizontal line shows the expression of a gene in different groups. The expression of such a gene is significantly different in at least one of the pairwise comparisons between different groups. Different colors indicate different levels of gene expression: from red to blue value ranges from high to low, respectively. Clusters numbers are on the left. Data from triplicate samples are shown. Datasets can be found in Additional file 3: Table S2. c Venn diagram of differentially-expressed genes in the brains of 5 DPI SVNI and CBE mice. The numbers of shared and unique genes are listed. Overlap was visualized using BioVenn