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. 2020 Aug 24;8:144. doi: 10.1186/s40478-020-01020-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Distinct patterns of microglia activation in brains of SVNI-infected versus nGD mice. Data were obtained from C57BL/6 mice untreated (control) or treated with CBE (50 mg/kg per day) from 13 day of age, uninfected or infected with a lethal dose (30 pfu, 3LD50) of SVNI on 21 day of age. a Immunofluorescence of brains of control, SVNI, CBE, and CBE + SVNI mice using anti-GAL3 (green) antibody. GAL3 staining was evaluated using ImageJ. Control, SVNI, CBE, and CBE + SVNI contain ~ 308 ± 16, 1548 ± 644, 663 ± 46, and 713 ± 92 GAL3-positive cells, respectively. Results are representative of three biological replicates. b Double immunofluorescence of brains of control, SVNI, CBE, and CBE + SVNI mice using anti-GAL3 (green) and anti-Tmem119 (red) antibodies. ×2 (upper panel) and ×20 (lower panel) magnification images. Data were obtained 5-DPI. Results are representative of three biological replicates