Table 2.
Impact of hyperthermic intraperitoneal chemotherapy regimen on perioperative outcome, n (%)
| Parameter | Total, n = 102 | Mitomycin, n = 34 | Oxaliplatin/5-FU, n = 68 | P value1 |
| Median operative time in min | 379 (95-774) | 410 (95-774) | 363 (96-722) | 0.260 |
| Median blood substitution in mL | 105 (0-1800) | 185 (0 -1800) | 66 (0-1200) | 0.068 |
| Hospitalization in d | 12 (2-46) | 11,4 (4-35) | 12,4 (2-46) | 0.315 |
| ICU stay in d | 6.3 (2-50) | 4.4 (2-9) | 7.2 (2-50) | 0.035a |
| In-hospital mortality | ||||
| Rate of complications | 57 (56) | 12 (35) | 45 (66) | 0.003b |
| Cardio-pulmonary morbidity | ||||
| Pneumonia | 5 (5) | 2 (6) | 3 (4) | 0.542 |
| Re-intubation | 2 (2) | 0 | 2 (3) | 0.442 |
| Pulmonary embolism/thrombosis | 2 (2) | 0 | 2 (3) | 0.442 |
| Hematoma | 2 (2) | 1 (3) | 1 (2) | 0.558 |
| Postoperative haemorrhage | 4 (4) | 1 (3) | 3 (4) | 0.593 |
| Surgical morbidity | ||||
| Intestinal atony | 23 (23) | 3 (9) | 20 (30) | 0.015a |
| Wound infection | 15 (15) | 5 (15) | 10 (15) | 0.608 |
| Abdominal abscess | 13 (13) | 5 (15) | 8 (12) | 0.448 |
| Abdominal infection | 15 (15) | 1 (3) | 14 (21) | 0.013a |
| Burst abdomen | 8 (8) | 1 (3) | 7 (10) | 0.184 |
| Peritonitis | 6 (6) | 0 | 6 (9) | 0.081 |
| Sepsis | 6 (6) | 0 | 6 (9) | 0.081 |
| Renal complications | ||||
| Urinary retention | 4 (4) | 0 | 4 (6) | 0.192 |
| Renal failure | 7 (7) | 2 (6) | 5 (7) | 0.344 |
| Urinary tract infections | 8 (8) | 0 | 8 (12) | 0.034a |
| Severity of complicationsb | 0.029a | |||
| Grade 0/I | 45 (44) | 22 (65) | 23 (34) | |
| Grade II | 23 (23) | 3 (9) | 20 (30) | |
| Grade IIIa | 16 (16) | 5 (15) | 11 (16) | |
| Grade IIIb | 10 (10) | 3 (9) | 7 (10) | |
| Grade IV | 8 (8) | 1 (3) | 7 (10) | |
| Grade V (in-hospital mortality) | 0 | 0 | 0 | |
| Mortality | 0.139 | |||
| 30 d | 5 (5) | 4 (12) | 1 (1) | |
| 90 d | 11 (10) | 5 (15) | 6 (9) |
1
Mann-Whitney U test/Fishers exact test.
a
P < 0.05.
b
P < 0.01. 5-FU: 5-Fluorouracil; ICU: Intensive care unit.