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Effect of changing the TFL administered in the second immunization (TFL2), conditioned on (A, D) a low TFL administered in the first immunization (TFL1), (B, E) an intermediate TFL1, and (C, F) a high TFL1, on the mean clonal breadth (A–C) and bnAb titers/GC (D–F) after the second vaccine immunization. Values in parentheses indicate the mean clonal breadth and bnAb titers/GC after the first immunization.
