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. 2020 Aug 3;117(33):20077–20087. doi: 10.1073/pnas.1919329117

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Fig. 6. — (A) Clonal diversity after the first vaccine immunization (variance in clonal breadth across all n = 1,000 GCs), conditioned on “success” in the second immunization (becoming a bnAb; clonal breadth >0.8). (B) Number of successful trajectories after the second immunization. (C–E) Mutational trajectories of individual clones across multiple vaccine immunizations and n = 1,000 GCs, for (C) a low TFL₁, (D) an intermediate TFL₁, and (E) a high TFL₁. Corresponding points in frustration space are indicated on the top plots.