Table 1.
KRAS variants | NRAS variants | |||||
WT (nM) | G12V (nM) | S17N (nM) | WT (nM) | G12V (nM) | S17N (nM) | |
ANBL-6 | ||||||
BTZ | 7 ± 0.25 | 16 ± 0.85 | 2.5 ± 0.19 | 11.5 ± 0.05 | 18 ± 0.25 | 3.5 ± 0.057 |
P = 0.031* | P = 0.052* | |||||
CFZ | 4.5 ± 0.28 | 12 ± 0.57 | 1.3 ± 0.21 | 6 ± 0.82 | 11.8 ± 1.06 | 3.6 ± 0.20 |
P = 0.031* | P = 0.031* | |||||
U266 | ||||||
BTZ | 0.9 ± 0.03 | 6.5 ± 0.33 | 0.1 ± 0.01 | 0.56 ± 0.02 | 1.8 ± 0.21 | 0.11 |
P = 0.041* | P = 0.031* | |||||
CFZ | 0.82 ± 0.03 | 3.5 ± 0.12 | 0.32 ± 0.02 | 0.42 ± 0.027 | 1.2 ± 0.034 | 0.2 ± 0.018 |
P = 0.031* | P = 0.031* |
P values are for the comparison between the G12V variants and the WT NRAS or KRAS.