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Schematic of the molecular mechanism of the ascorbic acid anticancer effect. SDHB-low PCPGs exhibit an imbalance in intracellular iron levels due to abnormal activation of the HIF signaling pathway, which further leads to increased vulnerability to oxidative stress. Targeting of the ROS synthetic pathway with pharmacologic doses of ascorbic acid could be a valuable therapeutic strategy for cluster I PCPGs with complex II deficiencies.
