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. 2020 Aug 24;11:363. doi: 10.1186/s13287-020-01862-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Matrilin-3 priming and culture condition optimization. a Live/dead assay. b mRNA expression of the apoptosis markers p53 and BAX. c Human cytokine array analysis was performed to measure the growth factors and cytokines in the conditioned medium of Ad-MSCs and primed Ad-MSCs. d Expression of TGF-β1, TGF-β2, IL-10, GCSF, and MMP-1 levels normalized to positive control. e Expression of CCL-5, GDF-15, and IL-6 levels normalized to positive control. G1, Ad-MSC monolayer; G2, matrilin-3-primed Ad-MSC monolayer; G3, Ad-MSC spheroid (125 cells/microwell); G4, matrilin-3-primed Ad-MSC spheroid (125 cells/microwell); G5, matrilin-3-primed Ad-MSC spheroid (250 cells/microwell); G6, matrilin-3-primed Ad-MSC spheroid (500 cells/microwell). Statistically significant expression at *p < 0.05, **p < 0.01, ***p < 0.001