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. 2020 Aug 24;11:363. doi: 10.1186/s13287-020-01862-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — T2-weighted MRI and histological analysis for assessing disc regeneration in a rabbit model. a Representative T2-weighted MRI scans of the sham, single Ad-MSC (ASC), matrilin-3 (MATN3) + single ASC, ASC spheroid, and MATN3 + ASC spheroid groups. b Disc regeneration was assessed by Masson’s trichrome staining. The results revealed that disc regeneration was the highest in the matrilin-3-primed ASC spheroid group. c The histological score for disc regeneration was the highest in the matrilin-3-primed ASC spheroid group. d The T2 signal intensity was the highest in the matrilin-3-primed ASC spheroid group, suggesting that the matrilin-3-primed ASC spheroid was the most effective for IVD regeneration (n = 7). G1, control; G2, only defect; G3, single Ad-MSC; G4, matrilin-3-primed single Ad-MSC; G5, Ad-MSC spheroid; G6, matrilin-3-primed Ad-MSC spheroid. ***p < 0.001, **p < 0.01, *p < 0.05