Table 3.

Meta-regression

	Variable	Subgroup	n	Overall estimate of meta-regression
				Sensitivity(95% CI)	p	Specificity(95% CI)	p
ASL	Region	China	14	0.89(0.84,0.94)	0.01	0.89(0.83,0.95)	0.71
		others	5	0.86(0.77,0.95)		0.94(0.88,1.00)
	Year	2008–2014	8	0.87(0.80,0.93)	0.00	0.88(0.80,0.96)	0.01
		2015–2019	11	0.89(0.83,0.95)		0.92(0.87,0.98)
	Number of patients	≤40	10	0.90(0.84,0.95)	0.00	0.93(0.87,0.99)	0.01
		>40	9	0.87(0.81,0.93)		0.88(0.81,0.95)
	Field strength	1.5 T	2	0.90(0.79,1.00)	0.21	0.96(0.90,1.00)	0.13
		3.0 T	17	0.88(0.83,0.93)		0.89(0.84,0.94)
	QUADAS-2 score	≤10	7	0.93(0.89,0.98)	0.00	0.94(0.89,1.00)	0.01
		>10	12	0.84(0.79,0.90)		0.88(0.81,0.94)
DSC-MRI	Region	China	4	0.94(0.83,1.00)	0.77	0.88(0.74,1.00)	0.14
		others	15	0.91(0.84,0.99)		0.80(0.72,0.88)
	Year	2006–2014	10	0.95(0.89,1.00)	0.07	0.80(0.69,0.90)	0.20
		2015–2017	9	0.87(0.74,0.99)		0.83(0.73,0.93)
	Age	≤45	9	0.94(0.87,1.00)	0.31	0.85(0.75,0.95)	0.03
		>45	10	0.90(0.80,1.00)		0.79(0.68,0.89)
	Number of patients	≤40	10	0.95(0.88,1.00)	0.33	0.89(0.82,0.95)	0.56
		>40	9	0.89(0.79,1.00)		0.72(0.62,0.83)
	Field strength	1.5 T	4	0.98(0.93,1.00)	0.23	0.76(0.60,0.92)	0.00
		3.0 T	15	0.90(0.82,0.98)		0.83(0.75,0.91)
	QUADAS-2 score	≤10	10	0.94(0.88,1.00)	0.14	0.86(0.77,0.95)	0.01
		>10	9	0.88(0.77,0.99)		0.77(0.66,0.88)
DKI	Region	China	9	0.89(0.83,0.95)	0.01	0.89(0.82,0.95)	0.01
		others	7	0.86(0.77,0.94)		0.81(0.69,0.92)
	Year	2010–2015	4	0.85(0.75,0.95)	0.14	0.89(0.79,0.99)	0.06
		2016–2019	12	0.89(0.84,0.94)		0.85(0.77,0.96)
	Age	≤48	9	0.85(0.78,0.92)	0.14	0.87(0.79,0.94)	0.02
		>48	7	0.91(0.85,0.97)		0.84(0.75,0.93)
	Number of patients	≤40	11	0.83(0.77,0.89)	0.32	0.88(0.81,0.94)	0.00
		>40	5	0.93(0.89,0.98)		0.80(0.70,0.90)
	QUADAS-2 score	≤10	10	0.84(0.78,0.91)	0.18	0.87(0.80,0.94)	0.02
		>10	6	0.92(0.87,0.97)		0.83(0.72,0.93)