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. 2020 Aug 24;17:126. doi: 10.1186/s12985-020-01400-3

Fig. 3.

Fig. 3

Specific humoral immune response and cytokine secretion produced by mice after immunization. In the third week after the mice were immunized three times with pV-JP3ME or pV, a IgG antibodies and b nAbs were produced with higher titers in the vaccine group than in the control group. One week after immunization, the mouse splenocytes produced high levels of c IL-2 and d IFN-γ upon JEV antigen stimulation. **P < 0.01, ***P < 0.001, n = 8 per group