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The origins of extracellular vesicles and the interactions of target cells. Exosomes and MVs have two different pathways of origin. Exosomes are formed by the endosomal system, while MVs are formed by direct membrane budding. Both of them contain proteins, lipids, and nucleic acids and interact with target cells through three pathways. MVB: multivesicular bodies; MVs: microvesicles.
