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. 2020 May 4;29:0963689720903691. doi: 10.1177/0963689720903691

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 4. — CORM-2 pretreatment attenuates the TNF-α-induced function damage of islets in ex vivo culture. (A) Immunofluorescence with insulin (green) and DAPI (blue) of islets pretreated with or without CORM-2 followed by 50 ng/ml TNF-α treatment for 72 h (control + TNF-α group, CORM-2 + TNF-α group) or the control islets alone (control group). Scale bars = 20 μm. (B) Quantification of insulin⁺ cells per islet. (C, D) Relative mRNA expressions of functional genes (C) and GSI (D) in islets pretreated with or without CORM-2 following with or without 50 ng/ml TNF-α treatment for 72 h. Fig. 3(C) and 4(D) share the same control data. Data are shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. CORM-2: carbon monoxide-releasing molecule 2; TNF-α: tumor necrosis factor-α; GSI: glucose-stimulated index.