Table 1.

The List of 14 Significant Biological Processes.

Biological Process	Count	p-value
G1/S Transition of Mitotic Cell Cycle	5	3.10E-05
Negative Regulation of Protein Kinase Activity	4	7.20E-04
Cell Cycle Arrest	4	2.00E-03
Negative Regulation of Cell Proliferation	5	5.10E-03
DNA Damage Response, Signal Transduction by P53 Class Mediator Resulting in Cell Cycle Arrest	3	5.50E-03
Negative Regulation of Monocyte Differentiation	2	1.20E-02
Regulation of Cell Cycle	3	2.10E-02
Replicative Senescence	2	2.10E-02
T-Cell Receptor Signaling Pathway	3	2.90E-02
Cellular Response to Extracellular Stimulus	2	3.20E-02
Response to Corticosterone	2	3.20E-02
Negative Regulation of Phosphorylation	2	3.50E-02
Negative Regulation of Cyclin-Dependent Protein Serine/Threonine Kinase Activity	2	3.90E-02
Cellular Senescence	2	4.00E-02

To analyze the involvement of DEGs in different biological functional groups, all 35 common genes between HL-60 and BV173 were annotated for their role in biological processes. Differentially expressed genes IDs were uploaded into online DAVID bioinformatics software, and functional annotation clustering analysis was performed on GOTERM_BP_FAT gene ontology (GO). Categories with a p<0.05 were considered as statistically significant. The software mapped 31 of 35 genes and highlighted 14 different biological processes in leukemic cells cultured in the presence of UC-MSCs.