Table 3.

The Most Important Signaling Pathways Altered in Leukemic Tumor Cell Lines in the Presence of UC-MSCs and their Respective DEGs.

Signaling Pathways	Gene Symbol
Cell cycle	MDM2, CCNE2, CDK6, CDKN1A, CDKN2A, DBF4
p53 signaling pathway	MDM2, CCNE2, CDK6, CDKN1A, CDKN2A
Chronic myeloid leukemia	MDM2, CDK6, CDKN1A, CDKN2A
MicroRNAs in cancer	MDM2, CCNE2, CDK6, CDKN1A, CDKN2A
PI3K-Akt signaling pathway	MDM2, COL6A3, CCNE2, CDK6, CDKN1A
Pathways in cancer	MDM2, CCNE2, CDK6, CDKN1A, CDKN2A

Further analysis using the KEGG database through the DAVID online bioinformatics tool highlighted the most interesting functional signaling pathways and their respective DEGs in HL-60 and BV173 cell lines.