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. 2020 Aug 24;11:366. doi: 10.1186/s13287-020-01883-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — tdTomato accurately traced photoreceptor precursor cells in 3D retinal organoids. a Immunocytochemistry with anti-CRX showing high correlation between tdTomato and CRX in D45, D60, and D90 organoids. Scale bar, 50 μm. b Quantification of anti-CRX-positive cells and tdTomato-positive cells at different stages of differentiation. c Immunocytochemical analysis between H9 and CRXp-tdTomato after retinal organoid differentiation indicates an undisturbed progenitor, ganglion cell, and rod development. Scale bar, 50 μm. d Quantification of ganglion, progenitor, and rod cells in D45, D60, and D90 organoids