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. 2020 Aug 24;20:796. doi: 10.1186/s12885-020-07298-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a) Gene Set Enrichment Analysis(GSEA) based on HALLMARK database. The result showed that the expression of several immune-related pathways were significantly upregulated in the group with high expression level of hub genes. b) The overall survival of high and low hub genes expression c) The expression of hub genes may be related to the better prognosis of HNSCC. The outlined square indicated a significant P value. The red rectangle showed the result of HNSCC population