Table 1.

NTs involved in different diseases and their targets

Disease	Neurotrophic factor(s)	Targets
Alzheimer’s disease	NGF, BDNF, and GDNF	Cholinergic neurons
Parkinson’s disease	GDNF/neurturin	Striatal neurons
Huntington’s disease	BDNF	Striatal neurons
Spinal cord injury	BDNF and NT-3	Site of injury
Supranuclear palsy	GDNF	Several in CNS
Amyotrophic lateral sclerosis (ALS)	NGF and BDNF	Motor neurons
Down syndrome	NGF	Cholinergic neurons
Sensory neuropathy	NGF	Sensory and sympathetic neurons
Overactive bladder (OAB)	NGF and BDNF	Bladder
Bladder pain	NGF	Bladder