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. 2020 Jul 31;205(5):1376–1384. doi: 10.4049/jimmunol.2000454

FIGURE 3.

FIGURE 3.

Siglecg−/− mice, which have excess B1a cells and B cell overactivation, have an exaggerated AKI immune response. (A) Representative flow cytometry plot showing WT and Siglecg−/− spleen CD19+B220low B cells. (B) Serum urea, weight loss, and extravascular kidney B cells 15 h following FA-AKI in WT and Siglecg−/− mice (n = 11 male mice in total). A parametric unpaired t test was used. (C) Extravascular kidney neutrophils and monocytes following FA-AKI, as described in (B). (D) Serum urea and neutrophil count following cisplatin-induced AKI (n = 8 male mice in total); a parametric unpaired t test was used. (E) Representative H&E histological images of renal tubules following cisplatin-induced AKI. (F) Serum urea 15 h following surgical renal pedicle clamping–induced AKI (n = 7 male mice in total). A parametric unpaired t test was used. (G) Serum urea and kidney neutrophils following sialic acid–treated cisplatin-induced AKI in WT mice (n = 11 male mice in total). A parametric unpaired t test was used. *p < 0.05, **p < 0.01, ****p < 0.0001.