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. 2020 Jul 9;37(9):3775–3790. doi: 10.1007/s12325-020-01409-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — LS mean change (95% CI) from baseline in a use of rescue medication; b percentage of rescue medication-free days over 52 weeks; c number of nighttime awakenings per week (ITT population). *p < 0.001 for FF/UMEC/VI compared with FF/VI or UMEC/VI.; **p ≤ 0.021 for FF/UMEC/VI compared with FF/VI. Note: a negative LS mean change from baseline indicates an increase in use of rescue medication. CI confidence interval, FF fluticasone furoate, ITT intent to treat, LS least squares, UMEC umeclidinium, VI vilanterol