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. 2020 Jul 28;20(4):3138–3146. doi: 10.3892/etm.2020.9066

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The Wnt/β-catenin signaling pathway is a potential target of MALAT1 in deep vein thrombosis. mRNA levels of Wnt/β-catenin-associated genes were affected by (A) LV-MALAT1 and (B) si-MALAT1 transfection, indicating overexpressed MALAT1 significantly altered the activity of the Wnt/β-catenin pathway, and vice versa. Western blot results confirmed that the protein levels of Wnt/β-catenin-related genes were also affected by (C) overexpressed or (D) silenced MALAT1 in endothelial progenitor cells. ^*P<0.05. MALAT1, metastasis associated lung adenocarcinoma transcript 1; LV-MALAT1, wild-type MALAT1; si-MALAT1, small interfering RNA targeting MALAT1; NC, negative control; DVL2, segment polarity protein dishevelled homolog DVL-2; GSK3β, glycogen synthase kinase 3β.