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. 2020 Aug 7;20(4):3709–3719. doi: 10.3892/etm.2020.9109

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Copyright: © Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CA attenuated pressure overload-induced cardiac fibrosis in mice. mRNA levels of (A) collagen I, (B) collagen III and (C) CTGF are presented in each group (n =15). (D) Protein expression of collagen I, collagen III and CTGF and (E) quantitative analysis in each group. (F) PSR staining for cardiac fibrosis and (G) statistical data on the percentage fibrosis of interstitial fibrosis in each group. (H) Masson staining in each group. (I) Immunohistochemistry staining for α-SMA protein (the arrows indicated the α-SMA in blood vessel) and the (J) quantitative analysis in each group. ^*P<0.05 vs. the vehicle + sham group. ^#P<0.05 vs. the vehicle + AB group. CTGF, connective tissue growth factor; PSR, picrosirius red; α-SMA, α-smooth muscle actin; CA, carnosic acid; AB, aortic banding.