Table 2.
Burdens in patients with hip and/or knee OA in the total population (US and EU cohorts; N = 2170) by pain intensity and opioid use
| No/mild pain without opioid use (n = 859) | No/mild pain with opioid use (n = 221) | Moderate/severe pain without opioid use (n = 663) | Moderate/severe pain with opioid use (n = 427) | |
|---|---|---|---|---|
| Physical function | ||||
| Mobility limitation (n = 2094) | 432 (52.4) | 149 (69.0)c | 498 (78.2)c | 362 (87.0)c |
| Need for walking aida (n = 1427) | 129 (30.0) | 67 (45.3)c | 225 (46.1)c | 243 (67.3)c |
| Need for help with daily activities (n = 2059) | 83 (10.2) | 46 (21.4)c | 183 (29.3)c | 197 (48.9)c |
| Suffered a fall (n = 2115) | 148 (17.6) | 47 (21.7) | 195 (30.6)c | 189 (45.3)c |
| Treatment needs | ||||
| Use of ≥ 3 treatment regimens for OA (n = 1965) | 102 (13.9) | 90 (40.7)c | 132 (22.7)c | 214 (50.1)c |
| Dissatisfaction with treatmentb (n = 1859) | 40 (5.8) | 22 (10.6)c | 144 (25.5)c | 153 (38.1)c |
| Comorbidity (N = 2170) | ||||
| Any cardiovascular condition | 421 (49.0) | 151 (68.3)c | 379 (57.2)c | 308 (72.1)c |
| Hypertension | 388 (45.2) | 142 (64.3)c | 355 (53.5)c | 283 (66.3)c |
| Depression or anxiety | 129 (15.0) | 49 (22.2)c | 146 (22.0)c | 147 (34.4)c |
| Osteoporosis | 51 (5.9) | 22 (10.0)c | 67 (10.1)c | 65 (15.2)c |
| Chronic low back pain | 52 (6.1) | 25 (11.3)c | 85 (12.8)c | 93 (21.8)c |
Values are the number (%)
EU European Union, OA osteoarthritis
aAmong those who reported mobility limitation
bAmong those currently treated
cp < 0.05 versus no/mild pain and no opioid use