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. 2020 Aug 10;16(8):e1008754. doi: 10.1371/journal.ppat.1008754

Fig 1. DENV2, ZIKV and CHIKV induced transcriptome regulation in A. aegypti salivary glands.

Fig 1

(A) Venn diagram shows numbers of uniquely and commonly regulated differentially expressed genes (DEGs) in DENV2 (green), ZIKV (red) and CHIKV (blue) infected salivary glands. Colorless area shows total number of unchanged genes. Arrows indicate the direction of regulation for the corresponding color code. (B) Functional annotation of DEGs in DENV2, ZIKV or CHIKV infected salivary glands. APO, apoptosis; BF, blood feeding; CS, cytoskeleton and structure; DIG, digestion; DIV, diverse functions; IMM, immunity; MET, metabolism; PROT, proteolysis; RSM, redox, stress and mitochondria; RTT, replication, transcription and translation; TRP, transport; UNK, unknown functions. (C) Transcriptomic regulation of the IMD and JNK pathways in DENV2, ZIKV and CHIKV infected salivary glands. First column represents a scheme of the JNK and IMD pathways partially, modified from Sim et al., [43]. In the following columns, boxes indicate DEGs with AAEL number below for DENV2, ZIKV and CHIKV. Arrows indicate the direction of regulation. Pink-filled boxes indicate genes regulated by more than one virus. Boxes with dotted line indicate DEGs selected for functional studies. Dark and light shaded green areas differentiate IMD from JNK pathways.