Table 2. Potentially inappropriate prescribing rates.
| N | Total person years of potentially inappropriate prescribing | Total person years of follow up | Potentially inappropriate prescribing rate per 100 person-years | IRR (95% CI) | IRR p value | |
|---|---|---|---|---|---|---|
| Total cohort | 25,016 | 72,453 | 57,707 | 125.6 | ||
| Age (years) | ||||||
| 66-<80 | 14,490 | 43,534 | 34,576 | 125.9 | Reference | 0.35 |
| ≥80 | 10,526 | 28,919 | 23,131 | 125.0 | 0.99 (0.98, 1.01) | |
| Sex | ||||||
| Male | 14,000 | 37,315 | 31,431 | 118.7 | Reference | <0.0001 |
| Female | 11,016 | 35,138 | 26,276 | 133.7 | 1.13 (1.11, 1.14) | |
| Index year | ||||||
| 2011 | 5,611 | 25,630 | 20,865 | 122.8 | Reference | |
| 2012 | 2,033 | 6,470 | 5,198 | 124.5 | 1.01 (0.99, 1.04) | 0.34 |
| 2013 | 3,737 | 11,344 | 8,835 | 128.4 | 1.05 (1.02, 1.07) | <0.0001 |
| 2014 | 4,786 | 12,516 | 9,997 | 125.2 | 1.02 (1.00, 1.04) | 0.08 |
| 2015 | 4,712 | 10,205 | 7,945 | 128.5 | 1.05 (1.02, 1.07) | 0.0001 |
| 2016 | 3,387 | 5,425 | 4,206 | 129.0 | 1.05 (1.02, 1.08) | 0.001 |
| 2017 | 750 | 864 | 662 | 130.4 | 1.06 (0.99, 1.14) | 0.08 |
| Potentially inappropriate prescription categories | ||||||
| Medications of concern in CKD | 25,016 | 12,156 | 57,707 | 21.1 | ||
| Medications of concern in older patients | 25,016 | 42,808 | 57,707 | 74.2 | ||
| Medications to be avoided at an eGFR <15 mL/min/1.73 m2a | 5,689 | 336 | 9,791 | 3.4 | ||
| Medications dispensed above the recommended dose for an eGFR <30 mL/min/1.73 m2 | 25,016 | 47 | 57,707 | 0.1 | ||
aExamined in sub-group of patients with a baseline eGFR <15 mL/min/1.73 m2.
Abbreviations: CKD, chronic kidney disease, eGFR: estimated glomerular filtration rate, IRR: incidence rate ratio.