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. 2020 Aug 21;15(8):e0237932. doi: 10.1371/journal.pone.0237932

Fig 2. FUD transiently decreased IOP in mice injected with Ad5-TGFβ2 viral vector.

Fig 2

(A) Graph shows IOPs measured on Days 0, 14 and 17 in mice injected with TGFβ2 adenovirus. On Day 15, some TGFβ2 transduced mice received intracameral injections of FUD, PBS or mFUD. FUD significantly decreased IOP on Day 17 (2 days after it was injected on Day 15; *p<0.05). n = 6, 15, 13 and 12 for TGFβ2 only, TGFβ2 + FUD, TGFβ2 + PBS and TGFβ2 + mFUD treated eyes respectively. (B) IOPs were monitored for 5 more days (until Day 22) in a subset of mice from A. Graph shows IOPs measured on Days 14, 17, 20 and 22 in mice injected with Ad5-TGFβ2 viral vector. On Day 15, some TGFβ2 transduced mice received intracameral injections of FUD, PBS or mFUD. FUD significantly decreased IOP on Day 17 (2 days after FUD injection) (*p<0.05). IOP then returned to baseline pre-FUD injection levels on Day 20 (5 days after injection). n = 10, 9 and 8 for TGFβ2 + FUD, TGFβ2 + PBS and TGFβ2 + mFUD treated eyes respectively. (C) Graph shows that injection of the Ad5.null viral vector containing no transgene had no effect on IOP (n = 4). No trt = contralateral eye that was uninjected. All graphs show mean ± SEM of IOPs at that time point. Statistical analysis was performed using an unpaired Student t-test.