Table 3. . Genetic associations with peripheral neuropathy sensitivity.

Entry	Genetic predictor	Genetic predictor distribution	Expected effect on PN Sensitivity	Beta†	95% CI	p-value
1	ARHGEF10: carrying rs9657362 or rs17683288	Yes: 21/58 = 36.2%	Lower	-0.27	-0.68–0.14	0.20
2	ARHGEF10: carrying any missense SNV	Yes: 30/58 = 51.7%	Lower	0.23	-0.16–0.63	0.25
3	SBF2: carrying rs117957652 or rs7102464	Yes: 18/58 = 31.0%	Higher	-0.32	-0.75–0.10	0.14
4	SBF2: carrying more functional SNV alleles	0: 21/58 = 36.2% 1: 26/58 = 44.8% 2: 11/58 = 19.0%	Higher	0.12	0.15–0.40	0.39
5	FGD4: carrying rs10844253‡	Yes: 36/58 = 62.1%	Higher	0.31	-0.09–0.71	0.13
6	FGD4: carrying any functional SNV	Yes: 17/58 = 29.3%	Higher	-0.07	-0.51–0.36	0.75
7	FZD3: carrying more rs7833751‡ alleles	0: 13/58 = 22.4% 1: 20/58 = 34.5% 2: 25/58 = 43.1%	Lower	-0.41§	-0.66 to -0.17§	0.0011§
8	NXN: carrying any functional SNV	Yes: 42/58 = 72.4%	Lower	-0.23	-0.66–0.20	0.29

^†Positive β-coefficient indicates higher PN sensitivity, negative indicates lower PN sensitivity. Bold indicates statistical significance (p < 0.05).

^‡These alleles are tagging SNV of the variant of interest (FGD4: rs10771973 and FZD3: rs7001034).

^§Statistical significance p < 0.05.

PN: Peripheral neuropathy.