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Coronal brain parametric PET images obtained with [11C]T1650. VT in monkey baseline scan (A) and in scan obtained at two hours after intravenous administration of BPN14770 (3 mg/kg,i.v.) (B). SUV in human brain at baseline (C), and at two hours after BPN14770 (single 50 mg oral dose) (D). BPN14770 showed a blocking effect in both monkey and human.
