Scheme 2.
Labeling of candidate PDE4D PET radioligands with carbon-11a.
aReagents and Conditions: a) H2, Ni, 360 °C; b) I2, 720 °C; c), either 1 M TBAH (for 3) or 1 M t-BuOK (15 μL, 3.15 μmol)(for 4–6) in DMF (80 μL), RT, 5 min.
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