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. Author manuscript; available in PMC: 2020 Aug 24.
Published in final edited form as: J Med Chem. 2019 Apr 23;62(10):4884–4901. doi: 10.1021/acs.jmedchem.9b00193

Figure 1:

Figure 1:

(1) Burgin et al. compound D1596877; (2) Naganuma et al. compound 3349; (3) Hagen et al. compound 8.50 The aliphatic substituents on the core project into a pocket of the active site known as the Q region.51 A pair of aromatic arms projects from the core. These have been labeled Ar1 and Ar2 as in Burgin et al.7