Skip to main content
. Author manuscript; available in PMC: 2020 Aug 24.
Published in final edited form as: J Med Chem. 2019 Apr 23;62(10):4884–4901. doi: 10.1021/acs.jmedchem.9b00193

Figure 2:

Figure 2:

PDE4D allosteric binding site. (A) view of a PDE4 dimer (PDB: 4WZI) showing the four-helix bundle and UCR2 from one subunit (colored red) positioned in trans- across the active site of the opposite subunit (colored blue).8 (B) Views of compounds 5 (PDB: 6NJI) and 6 (PDB: 6NJH) bound in the PDE4D allosteric site showing key polar contacts. Magnesium (green sphere), zinc (purple sphere), water (red spheres), UCR2 (cyan), and catalytic domain amino acid side chains (green).