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. Author manuscript; available in PMC: 2020 Aug 24.
Published in final edited form as: J Med Chem. 2019 Apr 23;62(10):4884–4901. doi: 10.1021/acs.jmedchem.9b00193

Scheme 1:

Scheme 1:

Synthetic schemesa

a Reagents and Conditions: a) EtCOCH2CO2Et, NaOMe; b) POCl3; c) H2NAr1, heat; d) BrCH2Ar1, Pd(dppf)Cl2; e) HOAr1, K2CO3; f) 3-Cl PhB(OH)2, Pd(Ph3P)4, K3PO4; g) 1) HSAr1, Et3N; 2) m-CPBA;