Table 2:

Inhibitory activity of cyclopentylpyridine Ar1 substitution^a

Compound	R	PDE4D7- S129D IC50 (nM)	PDE4B1- S133D IC50 (nM)	PDE4D7- S129(wt) IC50 (nM)	Ratio B/D	Ratio Basal/Activated
12	4-CH2CH2OH	9	562	2111	60	226
13	4-(CH2)2CONH2	35	166	1283	5	37
14	4-CH2CO-NMe2	51	356	914	7	18
15	4-CH2CO-N(H)Me	133	98	1991	1	15
16	3- CH2CH2OH	226	1419	6325	6	28
17	4-CH2CO2H	1165	1642	NTb	1	-

^aSee table 1 for assay definitions. See experimental section for methods and detailed synthetic procedures.

^bNT: Not tested