Table 4:

In vitro metabolism of compound 23 by human and rat hepatocytes.^a

Metabolites
	M1	M2	M3	M4	M5	M6	Parent
[M+H]+, m/z	558	558	558	382	382	367	366
Δ MW	+192	+192	+192	+16	+16	+1	-
Δ RT, min	−4.7	−4.4	−4.0	−3.0	−2.6	+2.2	-
Proposed Reactionb	moxy+ gluc	moxy+ gluc	moxy+ gluc	moxy	moxy	hydrolysis	-
Hepatocytes
Human	<1%	1.4%	-	2.5%	1.0%	<1%	93.2%
Rat	<1%	-	<1%	1.5%	1.5%	29.1%	66.8%

^apercentage of metabolite present is after 4 hour incubation with hepatocytes.

^bAbbreviations: moxy - monooxygenation; gluc -glucuronidation.