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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Cell Chem Biol. 2020 May 21;27(7):850–857.e6. doi: 10.1016/j.chembiol.2020.05.003

Figure 1. Identifying GSK923295-resistant clones derived from HCT116 or KBM7 cells.

Figure 1.

(A) Chemical structure of CENPE kinesin inhibitor (GSK923295).

(B) Analyzing toxicity of GSK923295 to HCT116 and KBM7 cells (KBM7: LD50 = 0.31 ± 0.02 μM, HCT116: LD50 = 0.25 ± 0.04 μM, average ± s.d., 72 h, n=3).

(C–D) Comparisons of toxicity (LD50) of GSK923925 (C), mitoxantrone (D), taxol (D) and ispinesib (D) to parental and resistant HCT116 and KBM7 cells (72 h, n = 3). For comparison, LD50 values for parental cells in the presence of GSK9123295 are also shown (C, data from B). See also Figure S1 and Table S1.