Table 2.
Transplant Characteristics and post-transplant immunoprofiling. Clonal isotype switch (CIS) occurrence correlated with more robust lymphocyte subset recovery after transplant.
| Without CIS (N=138) | With CIS (N=39) | P-value | |
|---|---|---|---|
| Pre-ASCT Weight (median, kg) | 84.6 | 81 | 0.131 |
| Pre-ASCT BMI (median) | 30.5 | 28.4 | 0.320 |
| Weight change (median, kg) | −3.7 | −4.65 | 0.313 |
| Weight change (median, %) | −4 | −6 | 0.278 |
| Pre-ASCT1 CD4/CD8 ratio (median) | 1.3 | 3 | 0.066 |
| Pre-ASCT1 CD8 cell (median, %) | 29 | 28 | 0.430 |
| Pre-ASCT1 B cell (median, %) | 24 | 28 | 0.233 |
| Pre-ASCT1 NK cell (median, %) | 19 | 22 | 0.369 |
| Total Nucleated Cells (median, × 10 ^8/kg) | 9.92 | 9.82 | 0.485 |
| Infused CD 34+ Cell Dose (median, × 10^ 6/kg) | 4.95 | 5.16 | 0.380 |
| Myeloid Precursors (CFU-GM) (median, × 10^4) | 105.2 | 109 | 0.343 |
| Erythroid Precursors (BFU-E) (median, × 10^4) | 189.4 | 182.6 | 0.288 |
| Mucositis (%) | 63 (46) | 14 (35) | 0.256 |
| Mucositis Grade (median) | 1.70 | 1.94 | 0.323 |
| Mucositis Length (median, days) | 5 | 7.5 | 0.279 |
| Length of Hospital Admission (median, days) | 15 | 16 | 0.315 |
| Post-ASCT ALC2 (median, × 10^9/L) | 1.03 | 1.345 | 0.167 |
| Post-ASCT AMC3 (median, × 10^9/L) | 0.46 | 0.445 | 0.345 |
| Post-ASCT ALC/AMC (median) | 2.53 | 2.84 | 0.143 |
| Post-ASCT CD4/CD8 ratio (median) | 0.2 | 2.8 | 0.001 |
| Post-ASCT CD8 cell (median, %) | 43 | 28 | 0.015 |
| Post-ASCT B cell (median, %) | 16 | 32 | 0.056 |
| Post-ASCT NK cell (median, %) | 17 | 21 | 0.291 |
| Maintenance therapy (%) | 85 (61) | 23 (58) | 0.437 |
1.
Bone marrow
2.
ALC: Absolute Lymphocyte Count
3.
AMC: Absolute Monocyte Count