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. Author manuscript; available in PMC: 2020 Aug 24.
Published in final edited form as: Clin Cancer Res. 2019 May 3;25(15):4663–4673. doi: 10.1158/1078-0432.CCR-18-4142

Figure 1: Distribution and frequency of T-cell PD-1, TIM-3 and LAG-3 expression in NSCLC.

Figure 1:

A) Representative fluorescence microphotographs showing the simultaneous detection of PD-1 (red), LAG-3 (white), TIM-3 (green) and CD3 (yellow) positive cells in NSCLC. B) Level of the markers measured using QIF in 2 retrospective NSCLC cohorts- Cohort #1 [n=426] (A) and #2 [n=304] (B). The markers were measured in CD3+ T-cells and showed a continuous distribution and strong association with CD3 (insets). The frequency of expression of each marker is indicated with white-colored text within the charts. R= Spearman’s correlation coefficient.