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Different types of antigens against which to design antibodies
| Target antigens for ADCs in preclinical and clinical development | |
|---|---|
| Cancer | Target antigens |
| Breast | CD174, GPNMB, CRIPTO and nectin-4 (ASG-22ME) |
| Ovarian | MUC16 (CA125), TIM-1 (CDX-014) and mesothelin |
| Lung | CD56, CD326, CRIPTO, FAP, mesothelin and GD2 |
| Pancreatic | CD74, CD227 (MUC-1) and nectin-4 (ASG-22ME) |
| Prostate | PSMA, STEAP-1 and TENB2 |
