TABLE 3.

Week 12 PASI response by tildrakizumab dose and by weight and region subgroups (exposure–response simulations)

Response	Subgroup	0 mg	25 mg	100 mg	200 mg	400 mg	Difference between 200‐ and 100‐mg groups	Difference between 400‐ and 200‐ mg groups
PASI75	≤90 kg	7	58	68	70	71	2	1
	>90 kg	5	44	57	60	62	3	2
	>120 kg	4	34	50	53	55	4	2
	>135 kg	3	31	47	51	53	4	2
	>150 kg	3	28	44	48	51	4	2
	Non‐Japan	6	51	63	65	67	2	1
	Japan	7	59	69	71	72	2	1
PASI90	≤90 kg	2	29	41	44	45	3	2
	>90 kg	1	17	27	30	32	3	2
	>120 kg	1	10	19	22	24	3	2
	>135 kg	1	9	17	20	22	3	2
	>150 kg	1	7	15	18	20	3	2
	Non‐Japan	2	23	35	37	39	3	2
	Japan	3	31	43	46	47	3	2
PASI100	≤90 kg	1	9	14	16	17	2	1
	>90 kg	0	5	9	11	12	2	1
	>120 kg	0	3	7	8	9	1	1
	>135 kg	0	3	6	7	8	1	1
	>150 kg	0	2	5	6	7	1	1
	Non‐Japan	1	7	12	14	15	2	1
	Japan	1	8	13	15	16	2	1

Data are presented as % of subjects.

PASI, Psoriasis Area and Severity Index.